CJC-1295 references separate the tested substances and subjects
This compound has a small body of human research. Here you'll find the papers behind the numbered claims, and links for checking the people and substances tested.
The numbered papers tell you which findings apply
The research compound CJC-1295 has only a few human studies. The numbered papers help you examine the evidence for a claim.
Teichman 2006 [1] and Ionescu/Frohman 2006 [3] measured hormone responses in healthy adults. Jette 2005 [2] examined the albumin bond; Alba 2006 [7] examined growth in mice lacking a growth-related hormone.
The papers also cover sleep, other blood proteins, related medicines, and cancer links, but you need each finding paired with the tested substance and the people or animals who received the substance. You can open the numbered links to read the original findings.
Scientists' and suppliers' reference lists disagree about the study compound's exact chemical make-up. Those lists describe substances, rather than testing what's inside a seller's bottle, so a result belongs to the tested compound and doesn't verify every bottle bearing its name.
The named human CJC-1295 studies chiefly measured blood
Teichman 2006 found larger hormone rises after larger amounts in healthy adults [1]. Growth hormone and IGF-1, the liver's growth protein, stayed raised for days.
Ionescu and Frohman 2006 found extra hormone between the usual bursts [3]. Sackmann-Sala 2009 found greater rises in other blood proteins when IGF-1 rose more [5].
These early CJC-1295 tests don't establish lasting benefits or safety for you. Development stopped at Phase 2, an early stage of examining treatment benefits and harm in patients.
The patients had HIV infection and excess fat deep inside the belly; HIV weakens the body's defence against germs. You still lack large studies following healthy adults for lasting benefits and harm.
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. ↗
- Jette L, Leger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005;146(7):3052-3058. ↗
- Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006;91(12):4792-4797. ↗
- Raun K, Hansen BS, Johansen NL, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. ↗
- Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009;19(6):471-477. ↗
- Steiger A, Guldner J, Hemmeter U, et al. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in normal men. Neuroendocrinology. 1992;56(4):566-573. ↗
- Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. ↗
- Gobburu JV, Agerso H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-1416. ↗
- Svensson J, Lall S, Dickson SL, et al. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation. Growth Horm IGF Res. 2001;11(Suppl A):S64-S65 (and related work, Bone 2000). ↗
- Granata R, Leone S, Zhang X, Gesmundo I, et al. Growth hormone-releasing hormone and its analogues in health and disease. Nat Rev Endocrinol. 2025. ↗
- Neuroendocrine circuit for sleep-dependent growth hormone release. Cell. 2025. ↗
- Falutz J, Allas S, Blot K, et al. Metabolic effects of a growth hormone-releasing factor analog (tesamorelin, TH9507) in HIV-infected patients with excess abdominal fat. J Clin Endocrinol Metab. 2010 (and related Phase 3 reports). ↗
- Body composition, hepatic fat, metabolic, and safety outcomes of tesamorelin. Obes Res Clin Pract. 2026. ↗
- Renehan AG, Zwahlen M, Minder C, O'Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004;363(9418):1346-1353. ↗
- (2026 peptide therapy safety review). Safety and efficacy of approved and unapproved peptide therapies for musculoskeletal conditions. Sports Med. 2026. ↗
- (GH sodium-retention study). GH increases extracellular volume by stimulating sodium reabsorption in the distal nephron. J Clin Endocrinol Metab. 2002. ↗
- (GHRH analog pulsatility/insulin study). Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity. J Clin Endocrinol Metab. 2011. ↗
- U.S. Food and Drug Administration. Pharmacy Compounding Advisory Committee (PCAC) meeting - briefing document on growth hormone secretagogues (CJC-1295). FDA Advisory Committee Briefing Materials. 2024. ↗
- ConjuChem Inc. (trial sponsor). A study to evaluate CJC-1295 in HIV patients with visceral obesity. ClinicalTrials.gov. 2006. ↗
- Reference summary. Modified GRF (1-29) - chemical and pharmacological description. Encyclopedic reference. 2024. ↗
- World Anti-Doping Agency. The Prohibited List - Section S2: Peptide Hormones, Growth Factors, Related Substances and Mimetics. WADA International Standard. 2025. ↗